Peri-nuclear clustering of mitochondria is triggered during aluminum maltolate induced apoptosis
نویسندگان
چکیده
منابع مشابه
Peri-nuclear clustering of mitochondria is triggered during aluminum maltolate induced apoptosis.
Synapse loss and neuronal death are key features of Alzheimer's disease pathology. Disrupted axonal transport of mitochondria is a potential mechanism that could contribute to both. As the major producer of ATP in the cell, transport of mitochondria to the synapse is required for synapse maintenance. However, mitochondria also play an important role in the regulation of apoptosis. Investigation...
متن کاملAluminum maltolate-induced toxicity in NT2 cells occurs through apoptosis and includes cytochrome c release.
Aluminum (Al) compounds are neurotoxic and have been shown to induce experimental neurodegeneration although the mechanism of this effect is unclear. In order to study this neurotoxic effect of Al, we have developed an in vitro model system using Al maltolate and human NT2 cells. Al maltolate at 500 microM caused significant cell death with a 24-h incubation and this toxicity was even more evid...
متن کاملAluminum-maltolate induces apoptosis and necrosis in neuro-2a cells: potential role for p53 signaling.
Aluminum maltolate (Al-malt) causes neurodegeneration following in vivo exposure, and apoptosis plays a prominent role. The objective of this study was to define the form of cell death induced by Al-malt and to establish an in vitro model system amenable to mechanistic investigations of Al-malt-induced cell death. Neuro-2a cells, a murine neuroblastoma cell line, were treated with Al-malt for 2...
متن کاملp53 is not necessary for nuclear translocation of GAPDH during NO-induced apoptosis.
Aberrant GAPDH expression following S-nitrosoglutathione (GSNO) treatment was compared in HepG2 cells, which express functional p53, and Hep3B cells, which lack functional p53. The results of Western blotting and fluorescent immunocytochemistry revealed that nuclear translocation and accumulation of GAPDH occur in both HepG2 and Hep3B cells. This finding suggests that p53 may not be necessary f...
متن کاملSodium valproate ameliorates aluminum-induced oxidative stress and apoptosis of PC12 cells
Objective(s): According to recent studies, valproate shows some protection against oxidative stress (OS) induced by neurotoxins. Current investigation tried to determine the possible ameliorating effects of sodium valproate (SV) against aluminum (Al)-induced cell death, apoptosis, mitochondrial membrane potential (MMP), and OS in PC12 cells.Materials ...
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ژورنال
عنوان ژورنال: Journal of Alzheimer's Disease
سال: 2006
ISSN: 1875-8908,1387-2877
DOI: 10.3233/jad-2006-9211